Lung Cancer

What is lung cancer?

Lung cancer is a common form of cancer in Hong Kong. Of the new cancer cases recorded in 2023, 6,111 were lung cancer cases, accounting for 16.1% of all new cancer cases. There were 3,576 cases among men and 2,535 among women, with a male-to-female patient ratio of approximately 1.4 to 1.

Because the early symptoms of lung cancer are often subtle, many patients are diagnosed at an intermediate or advanced stage, or even with stage IV lung cancer. Lung cancer is primarily classified into non-small cell lung cancer, NSCLC, (accounting for approximately 85%) and small cell lung cancer, SCLC, (accounting for approximately 15%).The TNM staging system described below is primarily used for NSCLC; in clinical practice, SCLC is also commonly described as limited-stage or extensive-stage disease.

At OncoCare, we understand the stress you and your family face when dealing with concerns about a potential diagnosis. Our oncologists provide comprehensive support throughout the entire process—from initial evaluation and personalised treatment plans to recovery or follow-up care. No matter what stage you’re at, we’ll be right by your side.

Be Aware of Early Signs and Common Symptoms of Lung Cancer

Early signs of lung cancer are often difficult to detect, which is why early detection and regular screening are crucial. Patients who are suspected of having or have been diagnosed with lung cancer may experience the following common symptoms:

  • Respiratory problems: A persistent cough that does not improve, wheezing, shortness of breath or difficulty breathing, or coughing up blood.

  • Pain and discomfort: Pain in the shoulders or chest (worsening with breathing), difficulty swallowing, which may occur if a tumour compresses or involves nearby structures.

  • Systemic symptoms: Unexplained weight loss, loss of appetite, unexplained tiredness or fatigue.

  • Recurrent infections: Chronic infections, such as recurrent bronchitis or pneumonia.

Some lung cancers may also cause specific syndromes, such as:

  • Superior Vena Cava (SVC) Syndrome—The superior vena cava is a large vein responsible for carrying blood from the head and arms to the heart. A tumour or enlarged lymph nodes near the lung or mediastinum may compress the superior vena cava, causing swelling in the face, neck, chest, and upper arms. 6

  • Paraneoplastic Syndromes — Some lung cancers produce hormone-like substances that affect other tissues and organs in the body. Some paraneoplastic syndromes include:
    • Cushing’s Syndrome — The adrenal glands may produce excessive cortisol (due to specific hormones produced by cancer cells), leading to weight gain, as well as symptoms such as dizziness, fatigue, and weakness. 6

    • Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) — Cancer cells can produce a hormone that causes the kidneys to retain water, thereby reducing salt levels in the blood. Symptoms may include: cramps and muscle weakness, fatigue, nausea, and/or vomiting. In severe and untreated cases, seizures and coma may occur.6

OncoCare’s Support: If you or a family member are experiencing the lung cancer symptoms mentioned above, please do not worry too much. Seeking an early evaluation from a clinical oncologist or pulmonologist is crucial. Through advanced medical imaging technologies such as low-dose computed tomography (LDCT), we can quickly and objectively assess lung health and ensure the best timing for treatment.

Our Tamarind Specialists Centre offers a lung health screening program. For details, please click here: Lung Cancer Screening: Don't Delay | Book Now |Tamarind Specialists . You may also click here to inquire or make an appointment via WhatsApp

Understanding the Causes and Risk Factors of Lung Cancer

Understanding the causes of lung cancer can help with early prevention and health management. The following are the main risk factors for lung cancer:

Smoking and Secondhand Smoke: Smoking is one of the most important and preventable risk factors for lung cancer. The exact proportion varies across populations, but smoking is strongly associated with a large proportion of lung cancer cases. Long-term exposure to secondhand smoke also increases the risk among non-smokers.

Environmental and Occupational Exposure: Long-term exposure to air pollution, asbestos (widely used as a building material), or other toxins (such as the radioactive gas radon).

Genetics and Medical History: Most cases result from sporadic mutations, and only in rare instances are they associated with hereditary genetic mutations. Furthermore, the risk increases with age or a history of conditions such as emphysema.

A Comprehensive Guide to Lung Cancer Staging: From Early Stages to Stage IV

After diagnosis, accurately assessing the stage of lung cancer is central to developing a personalized treatment plan. Doctors typically use the TNM system (which evaluates tumour size, lymph node involvement, and distant metastasis) for staging, where:

  • Tumour (T) — Describes the size of the primary tumour and the extent of local invasion. Smaller tumours may fall into the T1 category, while T4 may indicate a tumour larger than 7 cm, invasion into important nearby structures such as the mediastinum, heart, major blood vessels, trachea, oesophagus, or spine, or separate tumour nodules in a different lobe of the same lung.

  • Lymph nodes (N) — Describes whether the tumour has spread to nearby lymph nodes. Lymph nodes are classified into several stages, ranging from stage N0 (no lymph node spread) to stage N3 (cancer has spread to lymph nodes on the opposite side of the chest or in the clavicular region).

  • Metastasis (M) — Describes whether the cancer has spread to other parts of the body outside the lungs. Metastasis is graded from M0 (no spread) to M1c (the cancer has spread to distant organs).

Lung cancer is generally classified into the following stages:

  • Early-stage (Stages I and II): The tumour is mainly confined to the lung or nearby area. With early detection and appropriate treatment, the prognosis is usually favorable.

  • Locally advanced disease (some Stage II and stage III): The cancer may have spread to nearby lymph nodes or tissues within the chest but may not have distant metastasis.

  • Stage IV lung cancer (metastatic lung cancer): The cancer has spread to distant parts of the body, such as the bones, liver, brain, or adrenal glands.

Receiving a diagnosis of advanced or stage IV lung cancer is often unsettling. However, modern oncology has shifted its focus toward “living with cancer” and maintaining quality of life. Through the involvement of multidisciplinary medical teams and the use of comprehensive treatment plans—including genetic mutation testing, targeted therapy, immunotherapy, and palliative care—advanced-stage patients can receive more effective disease management and care.

Diagnosis

Diagnosing lung cancer involves several tests. You may need a bronchoscopy, which allows the doctor to directly examine your lungs; a mediastinoscopy, which uses a tube inserted through your neck and into the side of your windpipe to examine the mediastinum (the area between the two lungs); or a lung biopsy, in which a sample of tissue is removed from the tumour for testing.

Further tests may also be necessary to determine whether the cancer has spread to parts of the body outside the lungs. These tests include CT scans and virtual bronchoscopy, PET scans, or MRI.

OncoCare’s Personalised Care Approach

When it comes to lung cancer, we are committed to providing you with a patient-centered, personalized medical experience:

  • Early Screening, Early Detection, Early Treatment: Family medicine specialists provide personalized pre- and post-screening consultations for lung health, ensuring continuity of care throughout the process and offering personalized health recommendations based on your lifestyle and risk factors.

  • High-Privacy Consultation Environment: Our clinics are conveniently located in Central and Tsim Sha Tsui, offering you a comfortable and highly private specialist care setting.

  • Experienced Medical Team: Clinical oncologists will personally oversee your assessment and care.

  • Multidisciplinary Comprehensive Approach: We combine expertise from various specialties with evidence-based advanced technologies to tailor the most appropriate treatment plan for you.

  • Supporting the Whole Family: We understand that cancer affects the entire family. Our team provides full support throughout the journey—from diagnosis and treatment to recovery or follow-up care—ensuring peace of mind for both patients and caregivers.

Treatments

Frequently Asked Questions for Lung Cancer

I don’t smoke. Why did I develop lung cancer?
Although smoking is the most common cause of lung cancer, non-smokers can also develop the disease. Air pollution, long-term exposure to secondhand smoke, exposure to environmental toxins such as asbestos, and specific genetic mutations are all potential risk factors.
Early-stage lung cancer symptoms are subtle. How can I detect it early?
Early-stage lung cancer symptoms are indeed difficult to detect. If you belong to a high-risk group (e.g., those with a family history or long-term smokers), we recommend discussing the feasibility of regular lung imaging screenings with a specialist. OncoCare Cancer Centres can arrange a professional assessment with strict confidentiality.
If I’m diagnosed with stage IV lung cancer, are there still treatment options?
Generally, yes. With continuous advances in medical technology, there are now various treatment options available for stage IV lung cancer, including targeted therapy and immunotherapy, aimed at controlling the disease and maintaining the patient’s quality of life. Our multidisciplinary team is committed to developing a personalized treatment plan tailored to your needs.
Will the clinic provide guidance for my family during treatment?
Yes. At OncoCare, we uphold a “patient-centered” philosophy. Our team will guide you and your family through every stage of treatment, offering practical care guidance and emotional support.

References

For a full list of references, click here.
  1. Cancer Council. (2018). Lung Cancer. Retrieved on 22nd April 2019 from https://www.cancercouncil.com.au/lung-cancer/?gclid=EAIaIQobChMIhueBgeDk4QIVygorCh1USgkBEAAYASAAEgIrR_D_BwE#types
  2. American Cancer Society. (2016). What causes non-small cell lung cancer? Retrieved on 22ndApril 2019 from https://www.cancer.org/cancer/non-small-cell-lung-cancer/causes-risks-prevention/what-causes.html
  3. Genetics Home Reference. (2019). Chromosome 6. Retrieved on 22nd April 2019 from https://ghr.nlm.nih.gov/chromosome/6#conditions
  4. Genetics Home Reference. (2019). Lung Cancer. Retrieved on 22nd April 2019 from https://ghr.nlm.nih.gov/condition/lung-cancer#genes
  5. Australian Government: Cancer Australia. (2018). Lung Cancer. Retrieved on 22nd April 2019 from https://lung-cancer.canceraustralia.gov.au/symptoms
  6. American Cancer Society. (2016). Signs and Symptoms of Lung Cancer. Retrieved on 22nd April 2019 from https://www.cancer.org/cancer/lung-cancer/prevention-and-early-detection/signs-and-symptoms.html
  7. Cancer Council. (2018). Staging and prognosis for lung cancer. Retrieved on 22nd April 2019 from https://www.cancercouncil.com.au/lung-cancer/diagnosis/staging-prognosis/
  8. Australian Government: Cancer Australia. (2018). What are the risk factors for lung cancer?Retrieved on 25th April 2019 from https://lung-cancer.canceraustralia.gov.au/risk-factors
  9. Australian Government: Cancer Australia. (2014). Risk factors for lung cancer: an overview of the evidence. Retrieved on 25th April 2019 from https://canceraustralia.gov.au/system/tdf/publications/risk-factors-lung-cancer-overview-evidence/pdf/2014-risk_factors_for_lung_cancer_an_overview_final_lr.pdf?file=1&type=node&id=4062
  10. Australian Institute of Health and Welfare. (2011). Lung cancer in Australia: an overview. Retrieved on 7th November 2019 from https://www.aihw.gov.au/report/lung-cancer-in-australia-an-overview/contents/summary
  11. HealthyHK, Department of Health. (2019). Lung Cancer. Retrieved on 15 November 2019 from https://www.healthyhk.gov.hk/phisweb/en/healthy_facts/disease_burden/major_causes_death/cancers/lung_cancer/

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